Comparison of ADC Values Using Pulsed Field Gradient and Correlation Time Diffusion Techniques in a Murine Model of Steatohepatitis at 11.7T

نویسندگان

  • S. W. Anderson
  • J. A. Soto
  • H. N. Milch
  • H. Jara
چکیده

Methods: Imaging experiments were performed using 11.7T MRI. 22 male C57BL/6 mice were divided into a control group (n=2) fed normal chow and an experimental group (n=20) fed a methionine-deficient choline-deficient (MCD) diet used to induce steatohepatitis. The experimental diet was continued for a total duration of 81 days and mice were sacrificed intermittently throughout this period for ex vivo liver imaging.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Assessment of diagnostic value of DWI technique in the evaluation of liver fibrosis

Introduction: The liver fibrosis is caused by extracellular accumulation of cluster, glycos amino glycans and proteoglycans, which this extracellular accumulation may limit the penetration and molecular movement of water in the tissue, so the Diffusion weighted imaging(DWI) technique is due to the sensitivity to the movement and release of water molecules Can show this restrict...

متن کامل

Clinical Significance of Diffusion Weighted Magnetic Resonance Imaging on Treatment Efficacy in MS Patients With Acute Attacks

Background: Despite the existence of various imaging methods, the accurate diagnosis of many neurodegenerative diseases is still controversial. The use of advanced imaging techniques, such as the diffusion weighted imaging can be help the early detection of MS and evaluation of the treatment efficacy in these patients. Materials and method: 24 MS patients with acute attack and thirty healthy s...

متن کامل

Measurement of Apparent Long-Range Diffusion of He using Pulsed Gradient Spin Echo T2 in the Rat Lung at Low Magnetic Field Strength

Introduction: Measurement of Apparent Diffusion Coefficients (ADC) of hyperpolarized He gas in the lungs, can provide information on the micro-anatomical changes associated with disease over length scales permitted by the diffusion time. Improved sensitivity of ADC to chronic obstructive pulmonary disease (COPD) has recently been demonstrated using diffusion times on the order of seconds. These...

متن کامل

Diffusion weighted MRI in chronic viral hepatitis: correlation between ADC values and histopathological scores

OBJECTIVE To investigate the utility of apparent diffusion coefficient (ADC) measurement in the diagnosis of chronic viral hepatitis (CVH) and correlation between ADC values and histopathologic severity of CVH. MATERIALS AND METHODS The ADC values of liver parenchyma on diffusion-weighted magnetic resonance imaging (DWMRI) were measured in 50 patients with a history of CVH and 51 healthy subj...

متن کامل

Understanding the recuded ADC in stroke lesions using repeated measurements with different diffusion times

Introduction Diffusion MRI is a well known method for visualisation of acute and subacute ischaemic stroke lesions. However, the underlying mechanisms of the image contrast and of the reduced apparent diffusion coefficient (ADC) are still under debate. Influx of water into the intracellular space [1], an increased tortuosity in the extracellular space [2], shrinking of neurons [3] and reduced c...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2009